SHBG (Sex Hormone-Binding Globulin) Test: What It Measures and Why It Matters
SHBG is a protein made by the liver that binds testosterone and estradiol in your blood and controls how much is available to your body.
What the SHBG test measures
The level of sex hormone-binding globulin in your blood
Why we check it at Serene
SHBG explains why hormone numbers and symptoms don’t always match. High SHBG ties up more hormone, so you may have symptoms even with a “normal” total testosterone. It’s also used to calculate free testosterone.
At Serene Med Spa in Barboursville, West Virginia, every hormone and wellness plan starts with Labcorp lab work reviewed by a board-certified physician.
What your results can mean
Higher than normal
SHBG tends to rise with age, higher estrogen, an overactive thyroid, liver conditions and some medications.
Lower than normal
Low SHBG is often seen with insulin resistance, excess weight, an underactive thyroid and, in women, PCOS.
Normal ranges vary by lab, age and sex. Your physician reads every result together with your symptoms, history and other tests.
How to prepare
No fasting is needed. If you take biotin (vitamin B7) or a hair, skin and nail supplement, tell us first. The FDA warns that high-dose biotin can interfere with some lab tests, including hormone and thyroid tests.
It changes how much of your testosterone and estradiol is actually available, which helps your physician choose the right dose.
Insulin resistance, excess weight, an underactive thyroid and some conditions like PCOS are common causes.
Not by itself, but it can mean less free hormone is available, which can explain symptoms.
Have questions about your labs?
Book a hormone and wellness consultation at Serene Med Spa in Barboursville, WV. We’ll review your symptoms, order the right panel and walk you through every result.
Sources: MedlinePlus: SHBG Blood Test. This page is for general education and is not medical advice. Tests are ordered only after a consultation with a licensed provider.
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